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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
82 Results for "
Gentiana tibetica King ex Hook. f.
" in MedChemExpress (MCE) Product Catalog:
Products (82)
82 Results for "Gentiana tibetica King ex Hook. f." in MCE Product Catalog:
6
Category:
Cardiovascular Disease Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Rubiaceae Plants Disease Research Fields Indole Alkaloids
Target:
4
4
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3
3 Cited Publications
製品番号: HY-N8518
CAS 番号: 63335-25-1
Category:
Metabolic Disease Phenols Polyphenols Myristicaceae Plants Myristica fragrans Houtt. Disease Research Fields
Target:
3
3 Cited Publications
製品番号: HY-N5080
CAS 番号: 20013-23-4
Category:
Flavonoids Gentianaceae Phenols Polyphenols Plants Gentiana algida Pall. Disease Research Fields Inflammation/Immunology Isoflavones
Target:
2
2 Cited Publications
製品番号: HY-N2447
CAS 番号: 21018-84-8
1
1 Cited Publications
製品番号: HY-N2411
CAS 番号: 60314-89-8
Target:
1
1 Cited Publications
製品番号: HY-N2192
CAS 番号: 23445-00-3
製品番号: HY-N5037
CAS 番号: 109008-27-7
Category:
Cardiovascular Disease Aquifoliaceae Triterpenes Terpenoids Plants Disease Research Fields Tabernaemontana elegans Stapf
Target:
Target:
研究分野:
MS6105 is a PROTAC degrader targeting LDHA and LDHB, with DC50 values of 38 nM and 74 nM for degrading LDHA and LDHB in PANC-1 cells, respectively, and no hook effect is observed at high concentrations. MS6105 inhibits the proliferation of pancreatic cancer cells, and no obvious toxicity is observed after intraperitoneal administration in mice. MS6105 can be used for pancreatic cancer-related research .
製品番号: HY-N0476
CAS 番号: 84104-71-2
別名: Regelide; Abruslactone A
Category:
Triterpenes Terpenoids Celastraceae Plants Tripterygium wilfordii Hook. f. Disease Research Fields Inflammation/Immunology
Target:
製品番号: HY-N5070
CAS 番号: 176182-06-2
別名: Depressin
Target:
製品番号: HY-161108
CAS 番号: 2597167-34-3
Target:
研究分野:
PROTAC Chk1 degrader-1 is a Chk1-targeting PROTAC.PROTAC Chk1 degrader-1 recruits the Cereblon E3 ligase to induce ubiquitination and proteasomal degradation of Chk1.PROTAC Chk1 degrader-1 exhibits Chk1 degradation activity in malignant melanoma cells without showing a hook effect.PROTAC Chk1 degrader-1 can be used for the research of malignant melanoma .
製品番号: HY-N8305
CAS 番号: 25954-44-3
Target:
製品番号: HY-N4307
CAS 番号: 72361-67-2
Category:
Infection Alkaloids Phenols Polyphenols Plants Lauraceae Disease Research Fields Isoquinoline Alkaloids Lindera aggregata (Sims) Kosterm.
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製品番号: HY-N1072
CAS 番号: 37239-47-7
Category:
Terpenoids Sesquiterpenes Celastraceae Plants Tripterygium wilfordii Hook. f. Disease Research Fields Inflammation/Immunology
Target:
製品番号: HY-162331
Target:
STING Degrader-1 (compound 2), a molecular glue, is a potent STING degrader that covalently binds to STING and E3 ligase. STING Degrader-1 exhibits a "hook effect", that degrades 75% STING protein at 10 μM, and degrades ca. 30% STING protein at 30 μM .
製品番号: HY-169481
CAS 番号: 3027918-96-0
研究分野:
AP-1 is a targeted ALK PROTAC degrader. AP-1 effectively degrades various ALK fusion/mutation forms, including degradation of NPM-ALK (DC50 = 4.6 nM) and EML4-ALK (DC50 = 357.6 nM), and exhibits a typical hook effect at high concentrations. AP-1 inhibits phosphorylation of downstream STAT3, downregulates gene expression in the JAK-STAT pathway, and kills ALK-positive tumor cells via activating the caspase-3-dependent apoptosis pathway. AP-1 shows cytotoxicity against a variety of cancer cells and possesses anti-tumor activity. AP-1 can be used in research related to non-small cell lung cancer, neuroblastoma, and anaplastic large cell lymphoma .
製品番号: HY-N6256
CAS 番号: 108906-69-0
Category:
Cardiovascular Disease Aquifoliaceae Triterpenes Terpenoids Plants Disease Research Fields Tabernaemontana elegans Stapf
Target:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
